Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2198002 | Molecular and Cellular Endocrinology | 2007 | 7 Pages |
Abstract
In adrenocortical and Leydig cells PKA activation by trophic hormones increases the activity of protein tyrosine phosphatases and also induces the expression of MAP kinase phosphatase 1 (MKP-1), a dual activity protein phosphatase (serine/threonine and tyrosine). This work summarizes the knowledge on the regulation and the role played by cAMP-activated tyrosine phosphatases as well as MKP-1 in the hormonal activation of the acute and chronic phases of steroidogenesis.
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Authors
Alejandra Gorostizaga, Fabiana Cornejo Maciel, Laura Brion, Paula Maloberti, Ernesto J. Podestá, Cristina Paz,