| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2199290 | Molecular and Cellular Neuroscience | 2007 | 9 Pages |
Abstract
Inherited mutations to the tumor suppressor PTEN sporadically lead to cerebellar gangliocytoma characterized by migration defects. This has been modeled by CNS-specific PTEN ablation in mice, but the underlying mechanism cannot be explained by the known role of PTEN in Akt/PKB inactivation. Here we show that the loss of PTEN in mouse cerebellar neurons causes neurodegeneration by hyperphosphorylation of tau and neurofilaments, and activation of Cdk5 and pERK1/2, suggesting that dysregulation of the PTEN/pAkt pathway can mediate neurodegeneration.
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Authors
Naushaba Nayeem, Fiona Kerr, Heike Naumann, Jackie Linehan, Simon Lovestone, Sebastian Brandner,