Rare disease relations through common genes and protein interactions

•Orphan disease connections (ODCs) is a resource to explore potential molecular relations between rare diseases.•Disease relations are based on disease susceptibility genes and human protein-protein interactions.•Users can search, retrieve and explore in detail disease relations as well as other clinical data.•ODCs relations can be used to transfer knowledge between diseases and look for synergies between research lines.

ODCs (Orphan Disease Connections), available at http://csbg.cnb.csic.es/odcs, is a novel resource to explore potential molecular relations between rare diseases. These molecular relations have been established through the integration of disease susceptibility genes and human protein-protein interactions. The database currently contains 54,941 relations between 3032 diseases.