Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
220175 | Journal of Electroanalytical Chemistry | 2009 | 7 Pages |
The electrochemical oxidation of gabapentin has been investigated for the first time by cyclic, linear sweep and differential-pulse voltammetry at different pH at gold electrode. Cyclic voltammetric studies were performed in a wide range of sweep rates and various concentrations of gabapentin. The effect of surfactants was studied. The anodic peak was characterized and process was adsorption-controlled. The oxidation peak corresponds to the amine and probable mechanism was proposed. According to the linear relation between the peak current and the gabapentin concentration, differential-pulse voltammetric method for the quantitative determination in pharmaceuticals was developed. The linear response was obtained in the range of 0.3–15 μM with a detection limit of 0.13 μM with good selectivity and sensitivity. The proposed method was successfully applied to gabapentin determination in pharmaceutical samples and for the detection of gabapentin in urine as a real sample.