| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2201884 | Neurochemistry International | 2007 | 9 Pages |
Abstract
Three-dimensional structure–activity relationship studies of α2a-adrenoceptor agonists were carried out by Distance Comparison (DISCOthech) and Comparative Molecular Field Analysis (CoMFA) methods to define the pharmacophore and a quantitative model, respectively, of this class of compounds. The statistical validation of the CoMFA model indicates its high predictive performance for binding affinities of new α2a-adrenoceptor agonists.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Balázs Balogh, Balázs Jójárt, Zsolt Wágner, Péter Kovács, Gáspár Máté, Klára Gyires, Zoltán Zádori, György Falkay, Árpád Márki, Béla Viskolcz, Péter Mátyus,