| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2202357 | Results in Immunology | 2016 | 6 Pages |
Abstract
The thymus is the site of T cell maturation. Notch receptors (Notch1-4) and ligands (DLL1-3 and Jagged1-2) constitute one of several pathways involved in this process. Our data revealed differential constitutive expression of Notch genes and ligands in T lymphocytes and thymic dendritic cells (tDCs), suggesting their participation in human thymocyte maturation. nTreg analyses indicated that the Notch components function in parallel to promote maturation in the thymus.
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Authors
Luciana Bento-de-Souza, Jefferson R. Victor, Luiz C. Bento-de-Souza, Magaly Arrais-Santos, Andréia C. Rangel-Santos, Érica Pereira-Costa, Elaine Raniero-Fernandes, Maria I. Seixas-Duarte, João B. Oliveira-Filho, Alberto J. Silva Duarte,