| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2202634 | Seminars in Cell & Developmental Biology | 2014 | 10 Pages |
Abstract
•TGFA is an EGFR ligand.•TGFA surface delivery and cleavage are two important regulatory steps.•Forced expression of TGFA acts as epithelial mitogen and carcinogen.•TGFA interaction with NKD2 is required for its basolateral delivery.•TGFA is dysregulated in hyper-proliferative epithelial disorders.
Since its discovery in 1978 and cloning in 1984, transforming growth factor-alpha (TGF-α, TGFA) has been one of the most extensively studied EGF receptor (EGFR) ligands. In this review, we provide a historical perspective on TGFA-related studies, highlighting what we consider important advances related to its function in normal and disease states.
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Authors
Bhuminder Singh, Robert J. Coffey,