| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2202897 | Seminars in Cell & Developmental Biology | 2011 | 11 Pages |
Abstract
⺠Genomic copy number variations (CNVs) are a consequence of genomic re-arrangement and can be recurrent or non-recurrent. ⺠CNVs contribute to diversity, evolution but also pathological states in humans. ⺠CNVs can have unanticipated effects on gene expression, not just increases/decreases of genes within the region affected. ⺠Mechanisms underlying CNV formation can involve DNA breakage and/or alterations in replication fork strand priming. ⺠CNVs incorporating DNA replication and/or the DNA damage response genes can impact on the function of those processes.
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Authors
Rita Colnaghi, Gillian Carpenter, Marcel Volker, Mark O'Driscoll,