| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2203021 | Seminars in Cell & Developmental Biology | 2009 | 7 Pages |
Abstract
The Caenorhabditis elegans gonad provides a well-defined model for a stem cell niche and its control of self-renewal and differentiation. The distal tip cell (DTC) forms a mesenchymal niche that controls germline stem cells (GSCs), both to generate the germline tissue during development and to maintain it during adulthood. The DTC uses GLP-1/Notch signaling to regulate GSCs; germ cells respond to Notch signaling with a network of RNA regulators to control the decision between self-renewal and entry into the meiotic cell cycle.
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Authors
Dana T. Byrd, Judith Kimble,