| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2203055 | Seminars in Cell & Developmental Biology | 2010 | 7 Pages |
Abstract
X inactivation is the mechanism by which mammals adjust the X-linked gene dosage between the sexes. The dosage difference between XX females and XY males is functionally equalized by silencing one of the two X chromosomes in female cells. This dosage-compensation mechanism is based on the long functional Xist RNA. Here, we review our understanding of dosage compensation and Xist function in the context of disease.
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Authors
Ruben Agrelo, Anton Wutz,