Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2204253 | Trends in Cell Biology | 2015 | 4 Pages |
Abstract
Paired-end sequencing has enabled a variety of new methods for high-throughput interrogation of both genome structure and chromatin architecture. Here, we discuss how the paired-end paradigm can be used to interpret sequencing data as biophysical measurements of in vivo chromatin structure that report on single molecules in single cells.
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Authors
Viviana I. Risca, William J. Greenleaf,