Chromatin-Binding Proteins Moonlight as Mitotic Microtubule Regulators

Some microtubule (MT)-associated proteins bind to MTs and chromatin simultaneously to fulfill their mitotic spindle function. By contrast, a growing number of chromatin-binding proteins leave mitotic chromatin and interact with MTs via their chromatin-binding domains. I discuss this switch from chromatin to MT binding as a key regulatory principle of spindle formation.