| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2204389 | Trends in Cell Biology | 2014 | 9 Pages |
Abstract
•Chromatin features are altered in aging and in cancer.•Several changes to chromatin are common between aging and cancer.•Mechanisms by which aging-associated changes in chromatin may contribute to tumorigenesis can be envisioned.
Age is a major risk factor for cancer. Alterations in DNA methylation, histone modifications, chromatin structure, and epigenetic regulatory mechanisms are prominent hallmarks of both the aging process and cancer. Intriguingly – or possibly coincidentally – several chromatin features are common between aging and cancer. Here we ask whether, and if so how, aging-associated chromatin modifications contribute to tumor susceptibility and tumorigenesis.
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Authors
Linda Zane, Vivek Sharma, Tom Misteli,