Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2204622 | Trends in Cell Biology | 2014 | 10 Pages |
•The process of migration regulates the placement and differentiation of interneurons.•Interneuronal placement affects the excitatory/inhibitory balance in the cortex.•Changing networks of signaling pathways control decision-making steps of interneuron migration.
Appropriate interneuron migration and distribution is essential for the construction of functional neuronal circuitry and the maintenance of excitatory/inhibitory balance in the brain. Gamma-aminobutyric acid (GABA)ergic interneurons originating from the ventral telencephalon choreograph a complex pattern of migration to reach their target destinations within the developing brain. This review examines the cellular and molecular underpinnings of the major decision-making steps involved in this process of oriental navigation of cortical interneurons.