| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2205212 | Trends in Cell Biology | 2007 | 4 Pages |
Abstract
The molecular mechanisms required for sensing high osmolarity in the extracellular environment are not well defined in eukaryotes. A recent study showed that yeast Msb2 and Hkr1, which are related to mammalian mucins, are excellent candidates for sensing osmostress and for activating the HOG stress-activated protein kinase pathway involved in osmostress adaptation. Transmembrane mucins activate several signaling cascades in mammals and could therefore be important for sensing osmotic imbalances in higher eukaryotes.
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Authors
Eulàlia de Nadal, Francisco X. Real, Francesc Posas,