Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
221466 | Journal of Electroanalytical Chemistry | 2006 | 7 Pages |
Abstract
Immobilization and electro-oxidation of calf thymus double-stranded deoxyribonucleic acid (dsDNA) were investigated at carbon nanotube (CNT) electrode modified with ethylene diamine. Well-defined oxidation peak and large peak current of dsDNA oxidation have been observed even at very low dsDNA concentration (40 ng mL−1). Interaction between promethazine hydrochloride and immobilized dsDNA was also investigated. The intercalative binding of promethazine hydrochloride with dsDNA results in an increase of electrochemical impedance and a decrease of dsDNA oxidation peak current. The possibility using functional CNT electrode immobilized dsDNA to sense promethazine hydrochloride was also explored.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Chemical Engineering (General)
Authors
Hao Tang, Jinhua Chen, Kunzai Cui, Lihua Nie, Yafei Kuang, Shouzhuo Yao,