| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 227260 | Journal of Industrial and Engineering Chemistry | 2016 | 4 Pages |
•SiO2/Al2O3 nanocomposites (C-SLNs) were synthesized by chitosan as the template.•C-SLNs had higher specific surface areas, total pore volumes, and narrow mesopore size distribution.•C-SLNs was used as a levofloxacin carrier to study its drug release behavior.•C-SLNs exhibited an initial fast release followed by a sustained release and antibacterial effectiveness over a long period.
In this study, SiO2/Al2O3 composites (C-SLNs) were successfully synthesized using chitosan as the template for drug delivery. The C-SLNs had higher specific surface areas (244–607 m2/g), total pore volumes (0.19–0.34 cm3 g−1), and narrow mesopore size distribution. The porosity of the C-SLNs prepared under high Si/Al ratio conditions was achieved mostly by the formation of wider pores that were distributed in the meso-/macro-pores. And, the C-SLNs were used as a levofloxacin carrier to study its drug release behavior, which exhibited an initial fast release followed by a sustained release and antibacterial effectiveness over a long period.
Graphical abstractSiO2/Al2O3 composites were synthesized using chitosan as the template for drug delivery.Figure optionsDownload full-size imageDownload as PowerPoint slide
