Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
228879 | Journal of Industrial and Engineering Chemistry | 2010 | 5 Pages |
Abstract
Supercritical anti-solvent precipitation with enhanced mass transfer (SAS-EM) was applied for the production of micro and sub-microparticles of poly-lactic acid (PLA). SAS-EM technique uses an ultrasonic vibrating surface to enhance mass transfer rate between supercritical CO2 and solvent. Without applying ultrasonic power, which is same as SAS process, PLA particles with average diameters ranging between 1 μm and 3 μm were obtained. Using SAS-EM with the power supply of 200 W, spherical PLA particles smaller than 1 μm were obtained. The particle size was able to be controlled in the range of 0.4 μm–1.0 μm, by adjusting the power supply of ultrasonic field, the system pressure and temperature.
Keywords
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Chemical Engineering (General)
Authors
Sang Joon Park, Seoung Heon Choi, Hyon Hee Yoon,