Design of ionic liquid 1,3-disulfonic acid imidazolium hydrogen sulfate as a dual-catalyst for the one-pot multi-component synthesis of 1,2,4,5-tetrasubstituted imidazoles

Novel ionic liquid 1,3-disulfonic acid imidazolium hydrogen sulfate {[Dsim]HSO4} efficiently catalyzes the synthesis of 1,2,4,5-tetrasubstituted imidazoles via the one-pot multi-component condensation of benzyl with aldehydes, primary amines and ammonium acetate at 90 °C under solvent-free conditions. Dual hydrogen-bond donors can be used to direct the assembly of this catalyst and the efficiency of it.

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