Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
229382 | Journal of Saudi Chemical Society | 2016 | 6 Pages |
Abstract
A series of novel ethyl-5-amino-3-methylthio-1H-pyrazole-4-carboxylates 3a–j were synthesized from condensation of various hydrazides 2a–j with ketene dithioacetal. The synthesized compounds were screened for in vivo analgesic and anti-inflammatory activities using acetic acid writhing test in mice and carrageenan-induced paw edema test in rat, respectively. Diclofenac sodium was used as a standard drug for comparison. Compounds 3a, 3c and 3d exhibited significant analgesic and anti-inflammatory activities at a dose of 25 mg/kg and showed quite less ulcerogenic index in the range of 0.9–1.12 whereas diclofenac sodium showed 3.10.
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Physical Sciences and Engineering
Chemical Engineering
Chemical Engineering (General)
Authors
S.N. Thore, Sunil V. Gupta, Kamalkishor G. Baheti,