Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
229638 | Journal of Saudi Chemical Society | 2014 | 10 Pages |
Abstract
Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the treatment of pulmonary disorders such as asthma. During the process development of zafirlukast, eight process related impurities were observed at a level of 0.1–0.15 area percent. Synthesis and characterization of these impurities and investigation of the root cause of their formation is described.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Chemical Engineering (General)
Authors
Gilla Goverdhan, Anumula Raghupathi Reddy, Vurimidi Himabindu, Ghanta Mahesh Reddy,