Article ID Journal Published Year Pages File Type
229669 Journal of Saudi Chemical Society 2011 10 Pages PDF
Abstract

In the present work, carbonyl pyridoquinolones 8–33 were synthesized and their ability to inhibit gram-positive stains Bacillus subtilis and Staphylococcus aureus, gram-negative stains Escherichia coli and Pseudomonas aeruginosa, and fungi Candida albicans was studied. Carbonyl piperazines attached at C-3 position of pyridoquinolone exhibited good antibacterial activity when compared to the standard drugs ciprofloxacin and gatifloxacin. Indeed carbonyl piperazine derivatives 24–32 when attached at the C-3 position of pyridoquinolone increased the activity of their parent compound 6 than that of carbonyl ureas 8–23 exhibited lower antibacterial activity compared to carbonyl piperazine derivatives 24–32.

Related Topics
Physical Sciences and Engineering Chemical Engineering Chemical Engineering (General)
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