Solubility of chlorpheniramine maleate in supercritical carbon dioxide

•Solubility of chlorpheniramine maleate in SC-CO2 is measured.•Temperature and pressure are ranged between 308–338 K and 200–400 bar, respectively.•Solubility of chlorpheniramine maleate is between 1.54 × 10−5 and 4.26 × 10−4 (mole fraction).•Solubility data are correlated by MST, Bartle et al., KJ and Chrastil model successfully.

Solubility of chlorpheniramine maleate in supercritical carbon dioxide at different temperatures (308–338 K) and pressures (160–400 bar) is measured using static method coupled with gravimetric method. The measured solubility data demonstrated that the solubility of chlorpheniramine maleate was changed between 1.54 × 10−5 and 4.26 × 10−4 based on the mole fraction as the temperature and pressure are changed. The general trend of measured solubility data shows a direct effect of pressure and temperature on the solubility of chlorpheniramine maleate. Finally, the obtained solubilities correlated using four semi-empirical density-based correlations including Mendez Santiago–Teja (MST), Kumar and Johnston (KJ), Bartle et al., and Chrastil models. Although the results of modeling showed that the KJ model leads to the average absolute relative deviation percent (AARD %) of 8.1% which is the lowest AARD %, deviation of other utilized correlations are rather the same.

Graphical abstractThe self-consistency test of the measured chlorpheniramine maleate solubility using KJ model.Figure optionsDownload full-size imageDownload as PowerPoint slide