Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
230942 | The Journal of Supercritical Fluids | 2012 | 7 Pages |
In the present study, solubility of ketoprofen in the supercritical carbon dioxide was measured experimentally using gravimetric method. In this direction the temperature and pressure was ranged between 308.15–338.15 K and 160–400 bar, respectively. The obtained solubilites revealed that the ketoprofen solubility was in the range of 2.21 × 10−5 to 7.12 × 10−4 mole fraction according to the different temperatures and pressures. Measured solubilites demonstrated that pressure and temperature have a direct effect on the solubility enhancement. Finally, the least square method and curve fitting approaches were utilized to find the fitting parameters of four semi-empirical density based correlations including Mendez-Santiago–Teja, Bartle, Chrastile and Kumar and Johnston methods. The results revealed that Bartle et al. method was able to correlate the ketoprofen solubility with a minimum average absolute relative deviation (AARD %) of 5.95%.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Ketoprofen solubility was measured in a wide range of temperature and pressure. ► Ketoprofen solubility was in the range of 2.21 × 10−5 to 7.12 × 10−4 mole fraction. ► No crossover pressure was obtained for ketoprofen in this study. ► Solubilites were correlated via MST, Bartle, Chrastile and K–J empirical correlations.