Cetirizine solubility in supercritical CO2 at different pressures and temperatures

A simple static technique was used to obtain the solubility of cetirizine in supercritical carbon dioxide. The solubility measurements were performed at temperatures and pressures ranging from 308.15 to 338.15 K and 160 to 400 bar, respectively; resulting in mole fractions in the 1.05 × 10−5 to 4.92 × 10−3 range. The Chrastil, Bartle, Kumar & Johnston and the Mendez-Santiago and Teja (MST) models were used to correlate the experimental data. The calculated solubilities showed good agreement with the experimental data in the temperature and pressure ranges studied.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Simple static method was successfully used to measure the solubility of cetirizine. ► Solubility of cetirizine varied from 4.65 × 10−5 to 4.92 × 10−3 at different operating conditions. The obtained results reveal a rather sharp cross over pressure at 200 bar. ► The experimental data were correlated to four semi-empirical density-based correlations.