Encapsulation and co-precipitation processes with supercritical fluids: Fundamentals and applications

The formulation of natural substances together with a biocompatible or biodegradable carrier material to form composites or encapsulates has a great relevance for pharmaceutical, cosmetic and food industries. Several precipitation methods with supercritical fluids can be successfully adapted to produce these materials. This article presents a review of the main aspects of supercritical encapsulation and co-precipitation processes, focused on a process mechanisms description as well as of the types of materials that can be formulated with them.

Graphical abstractThe formulation of natural substances together with a biocompatible or biodegradable carrier material to form composites or encapsulates has a great relevance for pharmaceutical, cosmetic and food industries. Several precipitation methods with supercritical fluids can be successfully adapted to produce these materials. This article presents a review of the main aspects of supercritical encapsulation and co-precipitation processes, focused on a process mechanisms description as well as of the types of materials that can be formulated with them.Figure optionsDownload full-size imageDownload as PowerPoint slide