Article ID Journal Published Year Pages File Type
236594 Powder Technology 2013 8 Pages PDF
Abstract

Phase transformation of carbamazepine dihydrate during low pressure and atmospheric dehydration was investigated for a temperature range between 20 °C and 50 °C. The dihydrate was prepared by crystallisation from a mixture of ethanol and water, prior to dehydration studies at vacuum pressure (10− 3 to 102 Torr), 5% to 60% relative humidity (RH) and 5% to 90% solvent partial pressure (P/P0). During vacuum pressure dehydration, the dihydrate collapsed to the amorphous form undergoing quick liberation of water of hydration, before converting to a mixture of a metastable anhydrous C-monoclinic polymorph (major component) and a P-monoclinic polymorph (minor component) (Fig. 1). Humidified dehydration (≥ 30 °C) is shown to result in nucleation to a metastable triclinic polymorph, while organic solvent vapour-mediated phase transformation causes reversion to the most stable P-monoclinic anhydrate. The role of water and organic solvent during the dehydration process is investigated and discussed (in context with/with respect to) the molecular mobility and relaxation period required to initiate the nucleation of the more stable anhydrates. It is concluded that the dehydration mechanism itself as well as the metastability of the polymorphic anhydrate product eventually formed are determined by the accessibility of solvent vapour during the dehydration process.

Graphical abstractThis work highlights the role of surrounding solvent vapour (i.e. water vapour and dissolving organic solvents) during a dehydration process of a pharmaceutical channel hydrate–carbamazepine dihydrate. The nature of its dehydration mechanism depends on the accessibility and type of the surrounding vapour, which in turn determines the metastability of the polymorphic anhydrate formed.Figure optionsDownload full-size imageDownload as PowerPoint slide

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Physical Sciences and Engineering Chemical Engineering Chemical Engineering (General)
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