Supercritical antisolvent processing of γ-Indomethacin: Effects of solvent, concentration, pressure and temperature on SAS processed Indomethacin

γ-Indomethacin (IMC) is successfully processed with the supercritical antisolvent (SAS) technique. Pure, acicular (needle-like) particles of the α-polymorph are consistently obtained with SAS as the solvent, concentration, temperature and pressures are varied. Controlled changes in process parameters yield significant changes in particle size. Enhanced dissolution profiles are observed with IMC processed with SAS as opposed to the unprocessed IMC. The reduced particle size, as well as the α-polymorphic form of IMC, contributes to the enhanced dissolution rate.

Graphical abstractγ-Indomethacin (IMC) successfully processed with the supercritical antisolvent (SAS) technique exhibits significantly enhanced dissolution profiles when compared to the unprocessed IMC. Significant changes in particle size with a variation in process parameters are reported. Both particle size reduction and formation of α-polymorphic form of IMC contribute to the enhanced dissolution profile.Figure optionsDownload full-size imageDownload as PowerPoint slide