Parameter estimation in a multidimensional granulation model

A new multidimensional model for wet granulation is presented, which includes particle coalescence, compaction, reaction, penetration, and breakage. In the model, particles are assumed to be spherical and consist of two kinds of solid, two kinds of liquid, and pore volume. The model is tested against experimental results (Simmons, Turton and Mort. Proceedings of Fifth World Congress on Particle Technology, paper 9d, 2006) from the granulation of sugar particles with different PEG based binders in a bench scale mixer, being carried out for different impeller speeds, binder compositions and process durations. The unknown rate constants for coalescence, compaction, reaction, and breakage were fitted to the experiments and the sensitivities of the mass of agglomerates were calculated with respect to these parameters. This is done by employing experimental design and a response surface technique. The simulations with the established set of parameters show that the model predicts the trends, not only in time, but also for crucial process conditions such as impeller speed and the binder composition. As such it is found that more viscous binder promotes the formation of porous particle ensembles. Furthermore, the statistics of the different events such as collisions, coalescence and breakage reveal for instance that successful coalescence events outnumber the breakage events by a factor of up to three for low impeller speeds.

Graphical abstractA new multidimensional model for wet granulation is presented, which includes particle coalescence, compaction, reaction, penetration and breakage. A response surface approach is chosen in order to establish important model parameters of the subprocesses. The simulations show that the model predicts the correct trends, not only in time, but also for crucial process conditions such as the impeller speed and the binder composition.Figure optionsDownload full-size imageDownload as PowerPoint slide