The kinetics of the granulation process: Right from the early stages

In this study, experimentation and modelling were carried out to understand the granulation process. This work assesses whether there is a significant difference in the aggregation rate of the wet granulation process between the very early stages and later stages of high shear granulation. Measurements of the size distribution and binder content from the beginning of the process, just after liquid binder addition, were carried out. A population balance model based on two different kernels, the Equi Kinetic Energy (EKE) kernel and two-dimensional population balance equations with a Size Independent (SI) kernel, was applied to the high shear granulation process. It was concluded that the population balance equations with SI kernel best described the aggregation in the high shear granulation process. The value of aggregation rate constant in the early stages is smaller than aggregation kernel in the later stages.

Graphical abstractA population balance model based on two different kernels, the Equi Kinetic Energy (EKE) kernel and two dimensional population balance equations with a Size Independent (SI) kernel, was used to evalute the aggregation rate of granulation in the high shear mixer. It was found that SI kernel is the better model and the value of aggregation rate constant in the early stages is smaller than aggregation kernel in the later stages.Figure optionsDownload full-size imageDownload as PowerPoint slide