Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
239439 | Powder Technology | 2006 | 4 Pages |
Abstract
A small amount of solvents applied at the production of solid drugs is retained in the porous structure of the crystalline product. The regulatory guidelines require that the impurity due to the remaining solvent content of drugs should be a matter for serious concern toward marketing drugs; hence the reduction of the solvent amount is an important task of the technology of production. A steroid drug was crystallized and the correlation between the pore structure of the crystalline product and its residual solvent content was investigated. It was stated that the drug examined has a characteristic meso- and macropore structure, which distribution has a major contribution on the amount of the residual solvent content.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Chemical Engineering (General)
Authors
Magdolna Hasznos-Nezdei, József Kovács, Sándor Kováts, Amir Bashiri Shahroodi, Piroska Szabó-Révész,