Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2401374 | Tuberculosis | 2016 | 6 Pages |
Abstract
SummaryHIV-1 is recognized to increase the risk for tuberculosis even before CD4+ T cell deficiency is profound. To better understand how HIV-1 alters immunity to latent tuberculosis, we compared the magnitude and functional profile of mycobacteria-specific CD4+ T cells between HIV-uninfected and HIV-infected individuals, using flow cytometry. In HIV-1 infection, IFN-γ single positive mycobacteria-specific CD4+ T cells were decreased, while the frequency of polyfunctional cells (IFN-γ+IL-2+TNF-α+) remained unchanged. Moreover, the proportion of IFN-γ single positive cells correlated inversely with viral replication. Our results suggest that HIV-1 affects mycobacteria-specific cells differentially, depending on their functional capacity.
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Authors
Catherine Riou, Rubina Bunjun, Tracey L. Müller, Agano Kiravu, Zekarias Ginbot, Tolu Oni, Rene Goliath, Robert J. Wilkinson, Wendy A. Burgers,