Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2403076 | Vaccine | 2011 | 8 Pages |
Abstract
The zona pellucida 3 (ZP3), an autoantigen, once used to develop contraceptive vaccine has been faced a safety issue. Avoiding its pathogenic T cell activation, we intranasally co-delivered the mZP3 DNA- and protein-based vaccines in mice and observed that a higher level of sIgA and IgG antibodies in vaginal washes, bronchoalveolar lavages and serum and yielded a lower level of fertility and mean litter size. Importantly, histological analysis showed that normal follicular developments of the infertile mice were not disrupted in the co-delivered group. Thus, the intranasal co-delivery may present a safe strategy for the development of contraceptive vaccine.
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Immunology
Authors
Ailian Zhang, Jinyao Li, Gan Zhao, Shuang Geng, Shuzhen Zhuang, Bin Wang, Fuchun Zhang,