Effective protection induced by three different versions of the porcine S3Pvac anticysticercosis vaccine against rabbit experimental Taenia pisiformis cysticercosis

In an effort to develop an effective and affordable oral vaccine against porcine Taenia solium cysticercosis, the S3Pvac anti-cysticercosis vaccine was expressed in papaya calli. Taenia pisiformis experimental rabbit cysticercosis was used as a model to compare the efficacy of the oral vaccine vs. the injectable S3Pvac-synthetic and S3Pvac-phage versions.Oral S3Pvac-papaya significantly reduced the expected number of hepatic lesions and peritoneal cysticerci to a similar extent than the injectable vaccines. This study reports for the first time an effective oral vaccine against T. pisiformis cysticercosis, possibly useful against porcine T. solium cysticercosis.

► S3Pvac synthetic, S3Pvac-phage, S3Pvac-papaya protects against rabbit cysticercosis. ► Parenteral S3Pvac induced high similar protection than oral S3Pvac-papaya vaccine. ► S3Pvac components are expressed in Taenia pisiformis cysticerci and in oncospheres. ► Vaccination increased the inflammatory reaction surrounding established cysticerci.