Group B Streptococcus vaccination in pregnancy: Moving toward a global maternal immunization program

A group B streptococcus vaccine for pregnant women would add to the currently available vaccines given during pregnancy to protect mothers and their infants against serious and potentially lethal diseases, including tetanus, influenza, pertussis and meningococcal infection. Implementation of the administration of these high priority vaccines during routine prenatal care would result in a maternal immunization program with the potential to have a positive impact in public health globally, by reducing maternal and neonatal morbidity and mortality.

► Immunization during pregnancy can protect mothers and infants against tetanus, influenza and pertussis. ► A vaccine against GBS could be added to current maternal immunization programs. ► Introduction of a new vaccine requires understanding of the local epidemiology and impact of GBS. ► Research opportunities and challenges for a GBS vaccine for pregnant women are reviewed.