| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2403888 | Vaccine | 2012 | 7 Pages |
We determined the serotype and antimicrobial susceptibility of 1100 isolates responsible for adult invasive pneumococcal infections (IPD) in Portugal between 2006 and 2008. Serotypes 3 (13%), 1 (12%), 7F (11%), 19A (10%) and 14 (7%) were the most frequent causes of IPD and the two later serotypes accounted for the majority of erythromycin and penicillin nonsusceptible isolates. Serotype 1 was associated with younger adults whereas serotype 3 was associated with older adults. Despite the availability of the 23-valent polysaccharide vaccine (PPV23) in Portugal since 1996, the proportion of PPV23 preventable IPD remained stable and above 80%. Comparing with previous data from Portugal, we showed a continued decline of the serotypes included in the 7-valent conjugate vaccine (PCV7) in adult IPD and a rise of serotypes included in the 13-valent conjugate vaccine, increasing its potential coverage of adult IPD to 70% in 2008. Penicillin non-susceptibility remained stable (17%) whereas erythromycin resistance (18%) has continued to rise in the post-PCV7 years.
► We characterized invasive pneumococcal isolates from adults. ► We documented continued serotype changes after vaccination of children. ► Serotype 1 was associated with younger adults whereas serotype 3 with older adults. ► Potential coverage of the 13-valent conjugate vaccine increased to 70% in 2008. ► Potential coverage of the 23-valent polysaccharide vaccine remained stable >80%.
