Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2404238 | Vaccine | 2009 | 12 Pages |
Abstract
There is very limited evidence concerning the phenotype, function, and homing characteristics of memory T (TM) cells elicited by vaccination against intracellular bacteria in humans. Here we studied TM subsets elicited by exposure to Francisella tularensis in humans as a model of immunity to intracellular bacteria. To this end, TM cells were evaluated in two groups: (1) subjects immunized with live attenuated tularemia vaccine by skin scarification and (2) tularemia naturally infected subjects. In both groups the immune responses were mediated by CD4+ and CD8+ effector TM cells, mostly CD45RAâCD62Lâ and CD45RA+CD62Lâ. Based on the expression of CD27, integrins α4/β7, and α4/β1, it is likely that some of these TM cells have lytic potential and the ability to enter both mucosal and non-mucosal sites. Thus, regardless of whether by immunization or natural exposure, tularemia antigens elicited a broad spectrum of specific TM subsets with diverse homing characteristics.
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Immunology
Authors
Rosangela Salerno-Gonçalves, Matthew J. Hepburn, Sina Bavari, Marcelo B. Sztein,