Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2404241 | Vaccine | 2009 | 8 Pages |
Abstract
Listeria monocytogenes (Lm) holds promise as a neonatal vaccine vehicle. Here we show that Lm immunized neonatal mice reached maximal Ag-specific CD8+ T cell expansion after only a single immunization, while adults required two doses. Ag-specific CD4+ T cell expansion in both age groups required a boost to reach its peak. Neither functional avidity, sensitivity, nor the TCR-Vβ repertoire of the Ag-specific T cells differed between mice immunized as neonates or adults. Lastly, neonatal immunization did not decrease protection or preclude a booster response. Overall, our data provide further evidence in support of immunization at birth as a feasible public health strategy to combat early life infections.
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Authors
Kinga K. Smolen, Daniela I.M. Loeffler, Brian A. Reikie, Laura Aplin, Bing Cai, Edgardo S. Fortuno III, Tobias R. Kollmann,