Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2404353 | Vaccine | 2010 | 6 Pages |
Abstract
The amino terminal region of group A streptococcal M proteins evokes type-specific immunity while the conserved C-repeat epitopes evoke cross-protective immunity against multiple serotypes. The present studies were undertaken to compare the protective efficacy of vaccines containing either type-specific (hexavalent vaccine) or conserved C-repeat (J14 vaccine) M protein epitopes and to determine if combination vaccines resulted in enhanced levels of protection. Our results indicated that the protective efficacy of the type-specific vaccine was significantly greater than that of J14 and that the addition of J14 to vaccine formulations did not enhance the level of protection achieved with type-specific formulations.
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Authors
Thomas A. Penfound, Edna Y. Chiang, Elwaleed A. Ahmed, James B. Dale,