Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2404506 | Vaccine | 2010 | 9 Pages |
Abstract
Previously, we showed that the Shiga toxin type 2 (Stx2)-expressing Escherichia coli O157:H7 strain 86-24 colonized mice better than did its isogenic stx2 negative mutant. Here, we confirmed that finding by demonstrating that Stx2 given orally to mice increased the levels of the 86-24 stx2 mutant shed in feces. Then we assessed the impact of Stx2-neutralizing antibodies, administered passively or generated by immunization with an Stx2 toxoid, on E. coli O157:H7 colonization of mice. We found that such antibodies reduced the E. coli O157:H7 burden in infected mice and, as anticipated, also protected them from weight loss and death.
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Authors
Krystle L. Mohawk, Angela R. Melton-Celsa, Cory M. Robinson, Alison D. O’Brien,