| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2404750 | Vaccine | 2010 | 5 Pages |
Abstract
Tuberculosis remains a major human health problem worldwide, and strategies for its prevention include the generation and characterization of new recombinant vaccines containing immunodominant antigens from Mycobacterium tuberculosis. By comparing the secretomes of wild-type Mycobacterium bovis and a PstS1-recombinant M. bovis BCG vaccine substrain (rBCG38), we identified six conserved hypothetical proteins (BCG2696, BCG1674, BCG0372, BCG0427, BCG2436c, and BCG3053) that are differentially expressed. Our findings will aid in the identification of highly immunogenic proteins present in rBCG.
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Authors
Mauricio Rodríguez-Alvarez, Iliana D. Palomec-Nava, Guillermo Mendoza-Hernández, Yolanda López-Vidal,