Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2404951 | Vaccine | 2009 | 10 Pages |
Abstract
Studying the mechanisms of host survival resulting from viral encephalitis is critical to the development of vaccines. Here we have shown in several independent studies that high dose treatment with neutralizing antibody prior to intranasal infection with Venezuelan equine encephalitis virus had an antiviral effect in the visceral organs and prolonged survival time of infected mice, even in the absence of αβ T cells. Nevertheless, antibody treatment did not prevent the development of lethal encephalitis. On the contrary, the adoptive transfer of primed CD4+ T cells was necessary to prevent lethal encephalitis in mice lacking αβ T cell receptor.
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Authors
Nadezhda E. Yun, Bi-Hung Peng, Andrea S. Bertke, Viktoriya Borisevich, Jennifer K. Smith, Jeanon N. Smith, Allison L. Poussard, Milagros Salazar, Barbara M. Judy, Michele A. Zacks, D. Mark Estes, Slobodan Paessler,