Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2405181 | Vaccine | 2010 | 8 Pages |
Abstract
Pili of gram-positive bacteria are key virulence factors and their subunits are considered excellent vaccine candidates. Streptococcus suis is an emerging zoonotic agent that can cause epidemics of life-threatening infections in humans, but the functional role or immunoprotective potential of its pilus components have not been studied yet. Using a selective proteomics approach, we have identified a surface protein of serotype 2 S. suis showing features of an ancillary pilus subunit, as evidenced by bioinformatics analysis, immunoblot and immunoelectron microscopy. Immunization with recombinant fragments of this protein, designated herein as PAPI-2b, markedly protected mice from systemic S. suis infection.
Keywords
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Immunology
Authors
Manuela Garibaldi, Manuel J. Rodríguez-Ortega, Francesca Mandanici, Angela Cardaci, Angelina Midiri, Salvatore Papasergi, Orazio Gambadoro, Vittorio Cavallari, Giuseppe Teti, Concetta Beninati,