Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2405589 | Vaccine | 2009 | 6 Pages |
Abstract
Pharmacological manipulation of the balance between pro- and anti-inflammatory mediators emerges as a key aspect of a successful treatment of sepsis. A murine model of septic shock was developed and chosen conjugates (1a, 1b, 8a, 8c) and analogs (T2) of muramyl dipeptide and tuftsin were tested in this model as prospective anti-bacterial drugs or adjuvants. The phagocytic activity of monocytes/macrophages was determined (flow cytometry, bacterial clearance from vital organs). To evaluate cytokines levels (TNFα, IFNγ, IL6, IL10) we used real-time PCR. The most promising immunomodulatory properties were displayed by the analogue T2 and two conjugates: 8a, 8c.
Keywords
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Authors
Anna Wardowska, Krystyna Dzierzbicka, Magdalena Szaryńska, Maria Dąbrowska-Szponar, Katarzyna Wiśniewska, Andrzej Myśliwski, Piotr Trzonkowski,