Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2405614 | Vaccine | 2010 | 6 Pages |
Abstract
To define the capacity of a tetanus toxoid booster to reactivate infant-triggered immunity, anti-tetanus antibodies were assessed before and after boosting 162 adolescents and 219 children from Mfou (Cameroon). Among 63 adolescents with 3 recorded dose of infant DTP, 29/63 (46%) responded with a ≥4-fold increase of antibody titers, 35/63 (55%) reaching the 0.10 UI/ml threshold. Response rates were slightly higher (62%) in children aged 10–11 years. Responders and non-responders only differed significantly in their baseline anti-tetanus antibodies. Thus, early life immune immaturity may limit the persistence of infant-induced immunity and subsequent boosters may be required for sustained protection.
Keywords
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Immunology
Authors
Klara M. Posfay-Barbe, Marie Kobela, Cedric Sottas, Stéphane Grillet, Jean Taguebue, Tetanye Ekoe, Paul-Henri Lambert, Claude Lecoultre, Claire-Anne Siegrist,