Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2406210 | Vaccine | 2007 | 11 Pages |
Abstract
SummaryIn this study, we tested two triacylated pseudo-dipeptidic molecules, OM-197-MP-AC and OM-294-BA-MP as candidate adjuvants for allergy vaccines. Both molecules induce human dendritic cell (h-DC) maturation and polarize naïve T cells toward the Th1 type with IFNγ production. Only OM-294-BA-MP induces IL10 gene expression both in monocyte-derived DCs and CD4+ naïve T cells. Sublingual administration of OM-294-BA-MP plus the antigen enhances tolerance induction in BALB/c mice with established asthma to ovalbumin with an impact on both airways hyperresponsiveness and lung inflammation. Given its Th1/Treg polarizing properties, OM-294-BA-MP is a valid candidate for sublingual allergy vaccines.
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Authors
Laurent Mascarell, Laurence Van Overtvelt, Vincent Lombardi, Alain Razafindratsita, Hélène Moussu, Stéphane Horiot, Henri Chabre, David Limal, Stéphane Moutel, Jacques Bauer, Carlo Chiavaroli, Philippe Moingeon,