| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2406299 | Vaccine | 2009 | 4 Pages |
Abstract
Rift Valley fever virus (RVFV), which belongs to the genus Phlebovirus, family Bunyaviridae, is a negative-stranded RNA virus carrying a tripartite RNA genome. RVFV is transmitted by mosquitoes and causes large outbreaks among ruminants and humans in Africa and the Arabian Peninsula. Human patients develop an acute febrile illness, followed by a fatal hemorrhagic fever, encephalitis or ocular diseases, whereas ruminants experience abortions during outbreak. Effective vaccination of both humans and ruminants is the best approach to control Rift Valley fever. This article summarizes the development of inactivated RVFV vaccine, live attenuated vaccine, and other new generation vaccines.
Keywords
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Immunology and Microbiology
Immunology
Authors
Tetsuro Ikegami, Shinji Makino,