Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2406318 | Vaccine | 2007 | 7 Pages |
Abstract
To define the phenotypic characteristics and kinetics of T cell responses to a shingles vaccine in elderly individuals, 20 subjects ≥60 years of age received two doses of vaccine or placebo 6 weeks apart. VZV-specific T cell phenotypes and intracellular cytokines were determined by flow cytometry on blood mononuclear cells obtained pre-vaccination and up to 6 months after the second immunization. Results were compared with responses of five unvaccinated young adults. Pre-vaccination, elderly individuals had significantly lower VZV-specific effectors and cytokine-producing T cells compared with young adults. The vaccine significantly increased VZV-specific Th1, memory, early effector, and cutaneous homing receptor-bearing T cells.
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Authors
Julie Patterson-Bartlett, Myron J. Levin, Nancy Lang, Florian P. Schödel, Rupert Vessey, Adriana Weinberg,