Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2406331 | Vaccine | 2007 | 11 Pages |
Abstract
Pathogenesis of allergic inflammatory disorders is characterized by allergen-induced IgE stimulated by Th2 cytokines including mainly IL-4 overproduction. To counteract IL-4 effects in sensitized-BALB/c mice, we prepared an IL-4 derivative immunogen, made of KLH and murine IL-4 heterocomplex, termed mIL-4 kinoid. Murine IL-4 kinoid immunized mice produced high titer of anti-IL-4 neutralizing Abs. In contrast to KLH control immunization kinoid immunization reversed the allergic IgE:IgG ratio hallmark in rBet v 1a sensitized mice and reduced pulmonary eosinophil recruitment and bronchial hyperreactivity in Ova-sensitized mice. These data pave the way to alternative therapies to combat allergic conditions.
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Authors
Hélène Le Buanec, Sébastien Paturance, Isabelle Couillin, Silvia Schnyder-Candrian, Patrick Larcier, Bernhard Ryffel, Bernard Bizzini, Armand Bensussan, Arsène Burny, Robert Gallo, Daniel Zagury, Gabriel Peltre,