Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2406383 | Vaccine | 2008 | 11 Pages |
Abstract
SummaryIn this study, immunizations at 2 weeks vs. 6 weeks intervals, with an HIV-1 envelope protein in adjuvants, through intra-nasal (IN), intra-muscular (IM), IN followed by IM (IN/IM) and IM/IN, were compared for induction of mucosal and systemic immune responses. IN/IM immunizations at 2, but not at 6, week intervals induced the highest mucosal and systemic immune responses compared to other immunization routes. Following a resting memory phase, IN boosting of IN/IM-immunized mice, compared to IM-boosting of IM-immunized mice, induced increased IgA responses. Thus, depending on the immunization intervals, IN/IM may be more effective than IM immunizations for short- and long-term immunity.
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Authors
Indresh Srivastava, Amanda Goodsell, Fengmin Zhou, Yi Sun, Brian Burke, Susan Barnett, Michael Vajdy,